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Wednesday, December 2, 2009
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V Srinivasan, VK Pamula, RB Fair - Lab on a chip, 2004 - ncbi.nlm.nih.gov
SyBBURE Research Group
JOURNAL CLUB BLOG
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Welcome to the SyBBURE Journal Club
Rules:
Use the following format to when you enter your PreClass Reading Comment (PCRC) on each assignment
Your Name
Journal article first author's last name
1. Learned
2. Pressing ?
3. Presentation
4. Thoughts
Use the following format to when you enter your PreClass Reading Comment (PCRC) on each assignment
Your Name
Journal article first author's last name
1. Learned
2. Pressing ?
3. Presentation
4. Thoughts
Suggested Papers
An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human …
V Srinivasan, VK Pamula, RB Fair - Lab on a chip, 2004 - ncbi.nlm.nih.gov
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Funded by the Searle Systems Biology and Bioengineering Undergraduate Research Experience at Vanderbilt University
BLOG CONCEPT AND DESIGN BY AMANDA STARLING GOULD. 2009
Rosie Korman
ReplyDeletePaliwal
1. The individual response to the pheromone can vary within a yeast population at certain concentrations of pheromone due to bimodalilty in gene expression.
2. Why is this S. cerevisiae mating pathway important?
What is the shmooing/SHM phenotype?
Do other species of yeast or eukaryotes exhibit similar behavior?
3. Differences between the SHM and the budding phenotype pathways.
4.
Patrick Diggins
ReplyDeletePaliwal
1. Bimodal gene expression enables yeast cells to adjust to changing pheromone concentrations.
2. How do the yeast cells sense a gradient?
3. Mating pathways of varying organisms
Ayeeshik Kole
ReplyDeletePaliwal
1. The bimodality in gene expression allows the yeast to vary its response to pheromone signals, reducing risk of unnecessary gene amplification.
2. What is the relavence to SyBBURE research?
How can these findings be used to manipulate yeast mating?
3. Walking us through the signalling and transcriptional regulation in the pheromone MAPK pathway
Elizabeth Lillie
ReplyDeletePaliwal
1. The MAP kinases influence the sensitivity of gene expression in shmooing cells to pheromone concentration.
2. Does the MAP kinase exist in humans, does it play the same role?
3. Other papers on similar proteins.
Tommy Byrd
ReplyDeletePaliwal
1. A microfluidic chip-based experimental platform allows for the analysis of individual yeast cell response to long-term pheromone dose and gradient responses, revealing the importance of MAP kinases in in the yeast cell mating response.
2. What are the next steps in this research, considering the presented results? Why is it important to understand the biochemistry of mating yeast cells?
3. The role of pheromones in mating practices of other species
Liwei Jiang
ReplyDeletePaliwal
1. A microfluidic device was used to measure the effect of MAPK on Ste12.
2. Can you offer a better explanation of shmooing than "directed localized cell growth" or "prolonged chemotropism"?
3. Briefly outline the MAPK pathway, as MAPK is (I believe) an important regulatory protein in human cancer.