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JOURNAL CLUB BLOG

Sunday, November 15, 2009

sybbure journal club 11/17

here's the link to the article...hope it works

this link is to the pdf

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10 comments:

  1. LaurenNovember 16, 2009 at 1:04 PM

    1. They created an impedance-sensing system based off of cardiomyocite that can observe cardiomyocite hypertrophy. This system was created as a microfluidic device.
    2. Can you explain more in depth what is cardiomyocite hypertrophy. What causes it?
    3. The use of impedence-sensing systems for possible diagnosis of cardiomyocite hypertrophy in humans before there is any severe damage.

    ReplyDelete
  2. funny brainNovember 16, 2009 at 1:10 PM

    Niki Arinze

    Yang
    1. Using the dielectric properties of cells you can study hypertrophy with impedance measurements
    2. I'm having a hard time visualizing how all this looks with the cells in the device and how exactly the impedance shows hypertrophy? What is a confluent layer?
    3. Comparison in reliability of the impedance method to other in vitro measurement methods.
    4. Why would cells continue to hypertrophy outside of the body? Are there any in vivo methods to look at hypertrophy?

    4. How d

    ReplyDelete
  3. tesniemNovember 16, 2009 at 6:22 PM

    Tesniem Shinawi
    Yang
    1.A new cardiomyocyte-based impedance sensing
    system with the assistance of dielectrophoresis cell concentration was developed to monitor cardiomyocyte hypertrophy.
    2.Can you further describe the dielectrophoresis and how the sample forms a confluent cell monolayer?
    3.The dependability of the impedance sensing system and improvements needed.

    ReplyDelete
  4. Ayeeshik KoleNovember 16, 2009 at 7:07 PM

    Ayeeshik Kole

    Yang
    1. I learned that using this new sensing system with the assistance of a cell concentration method, the processes of endothelin-1-induced cardiomyocyte hypertrophy can be monitored at a greater sensitivity, reducing detection time.
    2. How exactly does DEP cell concentration work?
    3. The schematic/diagram of using this biosensor, as in how the set-up specifically works

    ReplyDelete
  5. Tommy ByrdNovember 16, 2009 at 7:11 PM

    Tommy Byrd
    Yang
    1.Microfluidic technology can be used for in vitro cardiomyocyte hypertrophy research.
    2.How could the technology presented in this paper be incorporated into a clinical setting?
    3.Dielectric properties of living cells and the implications of this characteristic

    ReplyDelete
  6. Elizabeth LillieNovember 16, 2009 at 7:13 PM

    Elizabeth Lillie
    Yang
    1. Endothelin 1 can be used on the cardiomyocytes in the DEP to test the impedence.
    2. How exactly does the dielectrophoresis work?
    3. Other papers using cardiomyocytes in microfluidics

    ReplyDelete
  7. Liwei JiangNovember 16, 2009 at 7:41 PM

    Liwei Jiang
    Yang
    1. Learned: A microfluidic device that measures impedance across a layer of cardiomyocytes was used to quantify cardiomyocyte hypertrophy.
    2. Pressing ? What are some of the possible factors that could cause the measured impedance to increase or decrease?
    3. Presentation: Briefly summarize the components of the impedance measuring device.

    ReplyDelete
  8. HussainNovember 16, 2009 at 8:41 PM

    Yang
    1. Current methods of monitoring cardiac hypertrophy in vivo are invasive and cumbersome. Yang et al. designed a microfluidic device that can monitor this process non-invasively and in real time.
    2. How sensitive and accurate is the data collected by this device?
    3. Could this technology be extended to cells other than cardiomyocytes?

    ReplyDelete
  9. AnonymousNovember 17, 2009 at 8:47 AM

    Peter DelNero
    Yang
    1) I learned about the DEP cell concentration method and that cell impedance can be used to detect cardiac hypertrophy.
    2) Can you please explain more specifically how DEP cell concentration works? Also, will you please refresh my memory of what impedance is?
    3) Paper on cardiac hypertrophy or cell concentration methods.
    4) It seems like that many layers of metal deposition would be harder to produce than most of our devices. How often do we deposit electrodes on our devices?

    ReplyDelete
  10. PatrickNovember 17, 2009 at 10:40 AM

    Patrick Diggins
    Yang
    1)Cardiac hypertrophy can be monitored using an impedance sensing microfluidic device.
    2)How are impedance and hypertrophy related?
    3)Techniques for monitoring heart hypertrophy

    ReplyDelete

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