Hi all-
Here is the article for this Wednesday:
Autologous Chemotaxis as a Mechanism of Tumor Cell Homing to Lymphatics via Interstitial Flow and Autocrine CCR7 Signaling
This is a biology paper that describes an interesting mechanism for tumor metastasis. Currently, a new microfluidic platform with live-cell imaging is being used to study this effect. The project emphasizes the simulation of tumor microenvironment. Looking forward to discussing on Wednesday.
-Peter and Alex
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Will Matloff
ReplyDeleteShields
1. A mechanism was found that explains how interstitial flow directs the migration of tumor cells.
2. How does this homing mechanism fit in with other tumor cell mechanisms? What is the relative importance of this finding?
3. A presentation could be given on autocrine signalling and chemotaxis. The use of microfluidics for the study of these topics could also be discussed.
Lindsay Chatfield
ReplyDeleteShields
1. The migration of tumor cells is directed by interstitial flow using autocrine CCR7 signaling.
2. How does this relate to microfluidics?
3. Other tumor metastasis mechanisms.
Trevan Locke
ReplyDeleteShields
1. The authors present a mechanism
explaining how interstitial flow directs tumor cell migration using autocrine CCR7 signaling.
2. What is the significance of this finding? Can it be used stop tumor cell migration?
3. How microfluidics could be used in this type of research.
Erik Werner
ReplyDeleteShields
1. A mechanism to describe tumor cell migration by IF and tumor-generated CCR7 gradients.
2. How could the CCL21 "block" (sulfated proteoglycans) be delivered to a patient in vivo?
3. Presentation on other forms of tumor metastasis
Rosie Korman
ReplyDeleteShields.
1. IF flow directs tumor migration.
2. Other mechanisms for tumor metastasis?
3. Relation to microfluidics
Erica Curtis
ReplyDeleteShields
1. IF and autocrine CCR7 signaling direct tumor cell migration.
2. What are the control mechanisms for CCL21/19? Using this knowledge, how could they be blocked in vivo?
3. How can this be studied using microfluidics?
Tang Dhummakupt
ReplyDeleteShields
1. Interstitial flow caused by the lymphatic system causes CCR7 dependent cell migration during cancer metastasis.
2. Could you explain more about how the IF increases the transcellular gradient across nearby tumor cells?
3. How this research can be applied to fighting cancer.
Chaitanya Allamneni
ReplyDeleteShields
1. Both interstitial flow and the CCR7 chemokine signaling direct tumor cell migration during metastasis.
2. Why would proteolysis increase flow? Is this tumor metastasis mechanism common for other cell types as well?
3. Altering flow/CCR7 concentration in a microfluidic device to study similar effects.
Jake Brady
ReplyDeleteShields
1.) Flow caused by the lymphatic system causes CCR7 dependent tumor cell migration during cancer metastasis.
2.) Please explain more in relation to interstitial flow and the CCR7 gradient
3.) How this research could be advanced/implemented using microfluidics