The article is Electroosmotic flow analysis of a branched U-turn nanofluidic device, Gea O. F. Parikesit, Anton P. Markesteijn, Vladimir G. Kutchoukov, Oana Piciu, Andre Bossche, Jerry Westerweel, Yuval Garinia and Ian T. Younga. Lab Chip, 2005, 5, 1067-1074.
The link is: http://www.ph.tn.tudelft.nl/People/albert/papers/05.Nanophoresis_LoC.pdf.
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Rosie Korman
ReplyDeleteParikesit, G
1. Parikesit et al. developed a nanofluidic device that can be used to detect single molecules in solution.
2. What are specific applications of detecting fluorescence in attoliter-sized volumes? Are they practical?
Why was the device designed with curved geometry?
How can the design of the device be altered to reduce Brownian motion?
3. Other possible designs for this nanofluidic device.
4. We just finished studying fluid dynamics in Biotransport, so the Navier-Stokes equation made me really excited.
Solve the N-S equations, and you can win a million dollars: http://www.claymath.org/millennium/Navier-Stokes_Equations/
ReplyDeletePeter DelNero
ReplyDeleteParikesit
1) methods for modeling fluid dynamics in microfluidic devices
2) Can similar experiments be conducted in PDMS devices? What are the benefits of using etched glass?
3)comparative study of micro and macrofluidic flow patterns
4)On the flight to Pittsburgh I sat next to a recent doctorate student who also used fluorescent particles to model fluid dynamics in a microfluidic environment. Why is this a big deal?
Niki Arinze
ReplyDeleteParikesit
1. analysis of electrosmotic flow in nonofluidic device designed for single molecule sorting.
2. I know that Brownian motion is a factor, but is it the only one? Could the deviations in the measured and expected paths be caused by something else?
Why are there 10 ports for 8 inlets? How does that work?
3. other uses of EOF
4. Does some at Vandy/in Viibre use electrosmotic flow?
Lei
ReplyDeleteParikesit
1. Learned: electrosmotic flow dynamics is analyzed and modeled in microfluidics models. Due to low Reynold's number, the flow can be analyzed as 2 dimensional analysis, but some other variations need to be considered. Many factors are involved such as Brownian motion.
2. Pressing: Explain electrosmotic flow in a general term. My own understanding, electrosmotic flow is the osmotic pressure due to applied voltage which produce a flow, is this right?
4. Thoughts: Is there any model to analyze real flow instead of electrosmotic flow. Such as apply a pressure around our blood pressure like 150mmHg, then the flow should be laminar flow and the fluid should be Newtonian fluid thus I think there should be a model for "near real flow"
Tommy Byrd
ReplyDeleteParikesit, G
1. The limiting factor in developing single molecule detection technology is being able to optically detect extremely small volumes of markers like fluorescence.
2. Can you come up with a specific non-existing application for SMD that could be used to treat existing carcinomas?
3. Biochemistry of fluorescent emission in chemical markers
4. What are the differences between ImageJ and Matlab?
Jennifer Greene
ReplyDeleteParikesit
1. The advantages of electroosmotic flow over pressure driven flow in a microfluidic device as well as the importance of defining and understanding the electroosmotic flow generated in a device
2. Could this be used for a PDMS device? Is the related to the u-pong work?
3. How electroosmotic driven flow could benefit other work in sybbure/viibre...how could it be used instead of the current syringe pumps. Is it a possible replacement or not?
Laurae Hicks
ReplyDeleteParikesit, et al.
1)Learned: Importance of a reliable SMD- ability to detect concentrations at very low volumes
2)Question: Can/Have SMDs been used for the early detection of any illnesses?
3) How does this relate to any VIIBRE/SyBBURE projects?
Holly Humphries
ReplyDeleteParikesit, et al.
1. Learned: That it is important to be able to detect concentrations at very low volumes.
2. Questions: Why exactly is it important to be able to detect single molecules? Specifically, what sorts of medical diagnostics require this ability? Also, if electroosmotic flow is easier to use, why do we use pressure-driven flow?
3. Optimizing sorting scheme to overcome Brownian motion issues.
Chaitanya Allamneni
ReplyDeleteParikesit, et al.
Learned: Electroosmotic flow can be measured within fluidic devices in order to detect small volumes from a single molecule.
Questions: Could electrosomotic flow be used rather than fluid flow in our microfluidic devices? Is is a future option?
Topic: Medical application of SMD
Parker
ReplyDeleteParikesit, et al
1. We probably won't be seeing any picofluidic devices.
2. Even at the increased potential differences, the effect of Brownian motion seems really high, as in high enough to cause significant variation between runs, no?
3. How small can you get before Brownian motion takes over the whole model of particle motion?
Liwei Jiang
ReplyDeleteParikesit
1. Learned: A nanofluidic device was developed. Electroosmotic flow inside the device was simulated and measured.
2. Questions: What is Hele-Shaw flow? Does any ionic solution (e.g. NaCl) generate electroosmotic flow?
3. Presentation: Reynolds number, Brownian motion
4. Thoughts: How is electroosmotic flow in a nanofluidic device useful in life?
Jinnah
ReplyDeleteParikesit, et al
1. Nanoscale fluidic devices can detect very small volumes and even single molecules.
2. Any biomedical applications of significance?
3. Explain what a numerical flow simulation is
Samat Kabani
ReplyDeleteParikesit
1. Using florescence, electroosmotic flow can be measured to detect small volumes of a single molecule in a fluidic device.
2. How easy/difficult is it to incorporate microelectrodes into a microfluidic device?
3. Comparison of Electroosmotic flow versus pressure-driven flow in fluidic devices
Elizabeth Lillie
ReplyDeleteParikesit et al
1. Electroosmotic flow can be used in nanofluidic devices to detect small molecules in the device.
2. What is a Reynolds number?
3. A paper about electroosmosis, not just nano scale