Peter DelNero
Sowinski
1) I learned about T-cell membrane nanotubes, and how they could play a role in intracellular transmission of HIV-1. These structures appear to accelerate transmission over long distance.
2)What would be the side-effects of targeting membrane nanotubes in HIV therapy?
3)How intracellular transport affects virulance- compare diffusion to other pathways
4)It seems very frightening that HIV can use T-cell nanotubes to rapidly spread. It's like an viral interstate. I'm curious about what else these nanotubes could be used for.
Subscribe to:
Post Comments (Atom)
Posts
Stephen Arndt
ReplyDeleteSowinski
1) I learned that the cell-cell transmission if HIV could be responsible for the accelerated viral transmission in vivo when antibody levels are elevated
2)What Is the normal physiological role of the nano tubes?
3)What are other non-standard pathogen transmission pathways
4)Why was HIV specifically picked out to study? There are many other pathogens that seem like they could use a similar pathway. Could the evolution of this mechanism account for the increase in the mortality rate of the pathogen over time?
Patrick Diggins
ReplyDeleteSowinski
1) The nanotubes created between T cells when they come into contact increase the transmission of HIV-1.
2) How do the nanotubes form between the T cells? Why do T cells form short-term intercellular unions?
3) Different ways in which cells interact
4) What happens to the nanotubes when the cells separate? Could nanotubes created by cells be harvested and used for other purposes?
Elizabeth Lillie
ReplyDeleteSowinski
1.) HIV-1 can transport quickly by means of nanotubles created between Jurkat T Cells.
2.) How often and frequently do the nanotubles form, what proteins/enzymes are involved in its contruction?
3.) Other viruses/infections/diseases that use the nanotubles as a means to spread and infect.
4.) What if the enzymes that made the nanotubles were somehow blocked when the cell was infected with HIV-1, would that stop further transmission?
Tommy Byrd
ReplyDeleteSowinski
1) T-cells can form HIV-transmitting nanotubes in a novel method of virion tranfer independent of intercellular diffusion
2)What other infectious agents could potentially be tranferred through these kinds of nanotubes?
3)Usual methods of creating virus vaccines
4)What does biomolecular pathway does the current (supposedly ineffective) HIV-1 vaccine target?
Sami Ayad
ReplyDeleteSowinski
1- T-Cells form nanotubes connecting one t-cell to another after contact, with frequencies of nanotube formation increasing after contact longer than 4 minutes, and that could be one of the ways that HIV-1 is transmitted between cells.
2)What are these nanotubes used for primarily? What is their function?
Would using a special treatment targeting these nanotubes also affect the immnune system for the worse, by affecting intracellular communication?
Are T-cells the only type of cells that create this kind of connection, in this manner? What about B-Cells or other cells?
Would MF devices be better for studying these nanotubes in comparison to the three dimensional mimic of extracellular matrix?
3- Pros and Cons of these nanotubes.
Liwei Jiang
ReplyDeleteSowinski
1. Learned: Nanotubes form between T cells after contact. A limited number of entities, including the HIV virus, can be transferred along nanotubes.
2. Pressing ?: What are some structural and functional differences between nanotubes and cell-cell connections derived from cell division?
3. Presentation: Have you had any luck recently in trapping Jurkat cells using your micro-compression device?
4. Thoughts: Is there a way to block the formation of nanotubes in HIV-infected T cells to slow the spread of the virus?
Parker Gould
ReplyDeleteSowinski
1) HIV can spread through nanotubes that form between T-cells.
2) I didn't understand the whole concept of "receptor-dependent"
3) I like Tommy's one about vaccine production. Especially with the whole H1N1 vaccine snafu.
4) Do these nanotubes break off, or recede back into the cells when the distance is too great, something gets in the way, etc.?
Chaitanya Allamneni
ReplyDeleteSowinski
1)T cells can form membrane nanotubes between each other which provides a possible route for HIV transmission.
2)I know nanotubes are just becoming a hot topic, but have their been viruses other than HIV which have been implicated with nanotubes for their transmission
3)Its been said above, but has blocking the formation of nanotubes been explored. What sort of means would one go about doing that?
Ayeeshik Kole
ReplyDeleteSowinski
1) HIV can be transferred via nanotubes over long distances and during short-term interactions in T-cells.
2) Do nanotube connections always exhibit a curvature? Or are they usually straight?
3) What sort of drug discovery research is being conducted after these major findings?
Jinnah
ReplyDeleteSowinski
1)One mechanism behind the persistent virulence of HIV may be the ability to form membrane nanotubes for inter-cellular communication.
2)How are nanotubes synthesized by the cell?
3)Have we found out about other retoroviruses similar to HIV using nanotubes for this purpose?
Harish
ReplyDeleteSowinski
1) How HIV can interact with T cells and nanotubes
2) How do nanotubes form?
3) Other viruses that can be transferred through nanotubes
4) I want to know more about the time scale of these interactions, particularly in lymph and blood
Jennifer
ReplyDeleteSowinski
1)Different ways HIV is transmitted between cells and how nanotubes have a role
2)What route is preferred or most common for a cells to transfer the virus
3)Do other viruses utilize this nanotube pathway?