Here is the article for this week's Journal Club on Wednesday. A pdf can be found here.
Thanks,
Rosie and Will
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V Srinivasan, VK Pamula, RB Fair - Lab on a chip, 2004 - ncbi.nlm.nih.gov
SyBBURE Research Group
JOURNAL CLUB BLOG
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Welcome to the SyBBURE Journal Club
Rules:
Use the following format to when you enter your PreClass Reading Comment (PCRC) on each assignment
Your Name
Journal article first author's last name
1. Learned
2. Pressing ?
3. Presentation
4. Thoughts
Use the following format to when you enter your PreClass Reading Comment (PCRC) on each assignment
Your Name
Journal article first author's last name
1. Learned
2. Pressing ?
3. Presentation
4. Thoughts
Suggested Papers
An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human …
V Srinivasan, VK Pamula, RB Fair - Lab on a chip, 2004 - ncbi.nlm.nih.gov
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Funded by the Searle Systems Biology and Bioengineering Undergraduate Research Experience at Vanderbilt University
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Trevan Locke
ReplyDeleteKuczenski
1. The authors developed a "chemical signal generator" using parallel laminar streams.
2. How do they prevent the ionomycin from diffusing into the other stream as the flow goes down the device?
3. Applications of this device that are not achievable in other device setups.
Liwei Jiang
ReplyDeleteKuczenski
1. The authors have built a device that generates controllable time- and spatially- varying chemical gradients.
2. Is there a direct (e.g. visual) way to check the concentration gradient at a given spot in the device?
3. Applications in which the time-variation of chemical signals matter a great deal.
Tang Dhummakupt
ReplyDeleteKuczenski
1. A device has been created that can manipulate the spacial-temporal concentrations of chemicals to elucidate regulatory mechanisms in response to disturbances.
2. If the cells are subjected to repeated or prolonged pulses of ionomycin and then allowed to rest, will a following pulse cause the same level of response?
3. More explanations on how the pressure regulators work.
Kuczenski
ReplyDelete1. A MF system has been created that can generate various waveforms of concentrations of chemicals.
2. What's going on at the top of Figure 1D?
3. How to build our own, but better. Specifically Joe's idea.
Kuczenski
ReplyDelete1. MF device that can track chemical wave signals
2. would this device work for all chemicals?
3. applications to learning about new chemicals
Kuczenski
ReplyDelete1. MF variable gradient generator- the position of the gradient could be adjusted based on the relative pressures of a neutral solvent and solution.
2. How specifically can you control the transcellular gradient when it is driven by diffusion? What are the limitations compared to a gradient that is established without relying on diffusion?
3. Importance of gradient chambers and challenges of simulating in vitro signals
4. Could you add extra channels with intermediate concentrations to widen the gradient? Would this be impossible to control the position of the gradient?